In the aftermath of the bus accident, House struggles with his head injuries and short-term memory loss, and must remember the symptom he saw before one of their own, who was on the bus with House, dies.
A bus accident leaves House with serious head trauma and partial amnesia. He comes to believe that a patient on the bus had a life-threatening disease and struggles to recall who it was, and what they had.
House believes that an actor on his favorite soap opera is seriously ill after observing his symptoms on television, so he decides to intervene; Amber and Wilson have their first fight, much to House’s delight; and Cuddy tries to keep up appearances when an inspector shows up unexpectedly at Princeton-Plainsboro.
House copes with a patient whose symptoms conceal a greater problem, but spends much of his time dodging Cuddy’s orders to give performance reviews, and fighting with Amber over who gets to spend more time with Wilson.
House and his team must diagnose a Jewish bride who is taken ill at her wedding. However, House is more interested in analyzing Wilson’s relationship with his new girlfriend.
House and his team have to diagnose a case at a distance when a researcher at a South Pole base is taken ill.
A mother’s sudden paralysis during a indoor rock-climbing incident leaves her daughter injured, and House’s new team looking for a cure. Meanwhile, House organizes his new recruits’ Secret Santa gift exchange… with a few twists of his own.
Under Cuddy’s pressure to choose his team, House gives the candidates a case of a former punk rock star who is a drug user. Whoever diagnoses the patient is going to have a future as a member of House’s team. Wilson misdiagnosed a cancer patient.
House treats a magician but comes to believe he’s faking illness to cover up his own incompetence. Meanwhile, House pits the fellows against each other in his version of an immunity challenge.
A film crew and the candidates are following around House distracting him while he is trying to diagnose a teenager who suffers from a heart 7777attack prior to a serious plastic surgery.